Mikan is the protagonist of the story. She is a cute, energetic, good-natured girl, but because of her clumsiness, she often gets into troubles. She is a cheerful and athletic person. She used to live with her grandfather in the country before transferring to Gakuen Alice.
She was shocked to hear that Hotaru was moving to an academy in Tokyo for young 'geniuses' like Hotaru. When she heard rumors that students were like slaves in Alice Academy (which she thought was a possibility, since they gave money to parents for sending their children to the school),Mikan became worried. Mikan left her grandfather and her home to go after Hotaru by herself. She was then accepted to Alice Academy by Narumi-sensei and could attend Alice Academy with Hotaru and many other children. She was later told by Narumi that the so-called Alice means a special power, not special academic results. At that time, Mikan didn't exactly know what's her Alice (power) was.
She discovers that her Alice is the Nullification Alice; an Alice which she inherited from her late father. The Nullficiation Alice can temporarily cancel out the powers of other Alices in close to her. She also possesses the Stealing and Insertion Alice, which she inherited from her mother, Yuka. All of her Alices are very rare and special. In the early episodes it was stated that her Nullification Alice was unstable and worked best when protecting people she feels strongly for. However, Mikan is later able to control and utilize her powers effectively with help from her teacher, Nodacchi-sensei, and her partner, Natsume Hyuuga.
At the beginning of the story, she was placed in the Special Abilities class, a class with students that have rare and uncommon Alices. Upon the discovery of her Stealing and Insertation Alice, she was transferred to the Dangerous Ability Class and became the Elementary Principal's 'special' student. She is currently a Single Star, but the rank will most likely be changed to Special Star upon discovery of her stealing Alice.